The epigenetic effects of butyrate: potential therapeutic implications for clinical practice

See https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/1868-7083-4-4

β-Hydroxybutyrate protects from alcohol-induced liver injury

Highlights •Liver BHB concentration is low in human AH, and reducing BHB in mice worsens liver injury after alcohol. •BHB supplementation reduced alcohol induced liver injury in wild-type but not Hcar2 deficient mice...

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

Butyrate, a short-chain fatty acid produced by the colonic bacterial fermentation is able to induce cell growth inhibition and differentiation in colon cancer cells at least partially through its capacity to inhibit histone deacetylases...